Other Enterobacteriaceae

De-escalation from IV cefepime to IV ceftriaxone is an option in patients with chromosomal Amp-C producing Enterobacteriaceae BSI secondary to low inoculum infections such as urinary source or central venous catheter infection s/p removal

However, IV therapy with cefepime is preferred in patients with deep-seated infections.

Transition to oral fluoroquinolones may be pursued in certain cases (if susceptible) pending appropriate source control and clinical improvement of the patient