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Antimicrobials
De-escalate to most effective and narrowest definitive therapy based on organism and infection
For treatment related questions contact PHASST
Following completion of definitive therapy, resume previous prophylaxis regimen OR consider initiation of prophylactic regimen if indicated based on risk factors
In patients deemed at intermediate or high risk of overall infection
The NCCN Guidelines Panel advises that fluoroquinolone prophylaxis (levofloxacin is preferred) be considered in patients with an expected duration of neutropenia (absolute neutrophil count [ANC] <1000 neutrophils/mL) for >7 days
In patients at low risk of overall infection
Neutropenia expected to last less than 7 days, and who are not receiving immunosuppressive regimens like systemic steroids, the NCCN panel suggests no antibiotic prophylaxis
