Spectrum: Local Antimicrobial Stewardship, for Prisma Health-Midlands

Non-Necrotizing Infection

Empiric Therapy

Vancomycin 15 mg/kg IV Q8-12h

  • Loading dose of 20 mg/kg once is recommended

  • Q8h dosing is preferred in young adults

PLUS EITHER

Piperacillin/tazobactam 4.5G IV Q6h

OR

Cefepime 2G IV Q8-12h

OR

Ciprofloxacin 400mg IV Q8h

Alternative (including for patients with severe penicillin allergy i.e. anaphylaxis, angioedema, hives, etc.)

De-escalation

De-escalate to narrower spectrum antibiotics based on rapid diagnostics and/or blood or tissue culture results