Spectrum: Local Antimicrobial Stewardship, for Prisma Health-Midlands

Risk Factors

Select All Applicable Fluoroquinolone Resistance Risk Factors

Avoid

Nitrofurantoin and Fosfomycin

  • In patients with suspected or documented pyelonephritis

  • The antibiotics do not concentrate outside the urine, including the interstitial cells of the kidney

Oral 3rd generation cephalosporins

For example:

  • Cefdinir

  • Cefpodoxime

Highly discouraged due to low urinary concentrations and higher risk of treatment failure in comparison to fluoroquinolones and SMX/TMP