β-Lactam Allergy

Minor Penicillin Allergies

Itching
Non-specific rash

Cross-reactivity with 3rd and 4th generation cephalosporins is low (<3%)

The benefit of β-lactam antibiotics outweighs the potential risk

Severe β-lactam Allergies + Low Risk of Fluoroquinolone Resistance

Anaphylaxis
No prior fluoroquinolone use within the past 12 months,
Non-residents of a nursing home or skilled nursing care facility, etc.

Ciprofloxacin 400mg IV Q8-12h

Severe β-lactam Allergies + Risk Factors For Fluoroquinolone Resistance

Consult Recommended

Contact Prisma Health-Midlands Antimicrobial Stewardship and Support Team (PHASST) during business hours or an infectious diseases specialist for optimal empirical antimicrobial therapy or evaluation for penicillin skin testing