Coagulase negative Staph

Consider contamination in the setting of a single positive blood culture or line tip positivity without a positive blood culture.

Repeat blood culture q48h until negative.

If susceptible, treat with cloxacillin or cefazolin.

With catheter removal, shorter duration appropriate with this organism (0 - 5 days), unless

patient has intravascular hardware (i.e. pacemaker, prosthetic valve), then longer duration required and must rule out endocarditis. Discuss with Infectious Diseases.

If isolate identified as S. lugdenensis, treat like S. aureus. Discuss with Infectious Diseases.

If catheter retention desired, appropriate only if fever and bacteremia resolve within 72h, no intravascular hardware, no IE or local signs of inflammation.