Mycoplasma and Chlamydophila pneumonia is rarely diagnosed due to the difficulty of isolating these pathogens. In rare instances, if it is identified by PCR on respiratory tract samples, directed therapy can be used.
Duration of treatment does not differ for these pathogens
Azithromycin duration is 500mg DAILY x 3 days or 500mg on day 1, followed by 250mg DAILY for 4 days. Longer durations are only indicated for Legionella
Macrolide resistance is possible and estimated to be ~10% in Canada. Switch to Moxifloxacin 400mg PO/IV if inadequate response
