Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

<3 Years Second-Line 1

Second-Line Treatment

Abacavir (ABC) 8 mg/kg/dose, twice per day (max: 300mg/dose)

For age <16 years or weight <37.5kg

OR

Tenofovir (TDF) 8 mg/kg, once per day (max: 300mg/dose)

For > 2-12 years

AND

Lamivudine (3TC) twice per day (max: 150mg/dose)

  • Age <30 days: 2 mg/kg/dose

  • Age >30 days: 4 mg/kg/dose

  • Weight >50kg: 150 mg

OR

Emtricitabine (FTC) once per day (max: 200mg/dose)

  • Liquid: 6 mg/kg

  • Capsule: 200mg

AND

Lopinavir/Ritonavir co-formulation (LPV/r) 230-350 mg/m², twice per day (max: 400mg/dose LPV + 100mg/dose RTV)

  • Preferred second-line regimen

  • Drug doses should be calculated according to body surface area

OR

Raltegravir (RAL) 1.5 mg/kg/dose

  • Alternate second-line regimen

  • Neonates ≥37wks and ≥2kg: OD

  • Infants/children >3kg to <20kg: BD

OR

Darunavir/Ritonavir co-formulation (DRV/r) 10-20 mg/kg, twice per day (max: 600mg/dose DRV + 100mg/dose RTV)

Can be used as an alternative PI option in special situations