Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Neonatal Meningitis Treatment

Duration

Continue IV antibiotic therapy for at least two weeks (GBS and Listeria) or three weeks (Gram negative bacteria) until CSF cultures are sterile

Initial Empirical Therapy

Ampicillin IV

AND

Gentamicin IV

AND

Cefotaxime IV

Continued Treatment

Reassess therapy based on culture and antibiotic susceptibility result

Group B Streptococcus

Discontinue aminoglycoside when clinically stable and CSF is sterile

Gram negative organism

Discontinue aminoglycoside after two weeks and complete course with cefotaxime alone