Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Adolescent Alternative 2

First-Line Treatment

Tenofovir (TDF) 8 mg/kg/dose, once per day (max: 300mg/dose)

For > 2-12 years

AND

Lamivudine (3TC) twice per day (max: 150mg/dose)

  • Age <30 days: 2 mg/kg/dose

  • Age >30 days: 4 mg/kg/dose

  • Weight >50kg: 150 mg/kg/dose

OR

Emtricitabine (FTC) once per day (max: 200mg/dose)

  • Liquid: 6 mg/kg

  • Capsule: 200mg

AND

Dolutegravir (DTG) once per day (max: 50mg/dose)

  • >30kg, <49kg: 35mg

  • ≥40kg: 50mg

  • Safety and efficacy data for the use of DTG in HIV/TB co-infected people <12 years is not yet available

Second-Line Treatment (If Failing First-Line Regimen)

AZT + 3TC + ATV/r (or LPV/r or DRV/r or DTG)

RAL + LPV/r