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APSGN may occur at any age, but it is most common between 2-15 years of age (median 6-8)
APSGN typically follows either pharyngeal (1-2 weeks later) or, less commonly, skin infections (3-6 weeks later) with group A Streptococcus (GAS)
Severity varies from asymptomatic microscopic hematuria to anuria causing renal failure
Gross hematuria occurs in 30-50% of cases
Volume overload occurs in up to 2/3 of patients and may be enough to cause congestive heart failure and pulmonary edema
Hypertension occurs in up to 80% of cases
Severity may not correlate with degree of volume overload
Hypertensive encephalopathy (seizure, confusion, and coma) is the presenting features in 5% of cases
