Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

TB Meningitis or Spinal TB

Intensive Phase

Isoniazid (H) 10 (10-15) mg/kg daily (max: 300mg/day), for 2 months

AND

Rifampicin (R) 15 (10-20) mg/kg daily (max: 600mg/day), for 2 months

AND

Pyrazinamide (Z) 35 (30-40) mg/kg daily, for 2 months

AND

Ethambutol (E) 20 (15-25) mg/kg daily, for 2 months

WITH OR WITHOUT

Streptomycin (S) 15 (12-18) mg/kg daily, for 2 months

Should be avoided whenever possible in children because the injections are painful and irreversible auditory nerve damage may occur

Continuation Phase

Isoniazid (H) 10 (10-15) mg/kg daily (max: 300mg/day), for 10 months

AND

Rifampicin (R) 15 (10-20) mg/kg daily (max: 600mg/day), for 10 months