Late Onset Sepsis (LOS)

Reinforce infection prevention and control procedures

Risk Factors

Duration

Antibiotics can either be continued or modified based on the culture report and clinical condition

If culture negative, consider stopping therapy
Continue therapy if sepsis is very likely even though culture comes back as negative

Situation-based duration

Situation	Duration
Clinical course and laboratory findings do not verify the suspected infection	48 hours (max.)
Infection is confirmed (evidence of pathogens + laboratory studies and/or clinical presentation)	7 days
Blood culture is positive and/or severe illness	10 days
Meningitis (some guidelines recommend treatment for an additional week after the last negative CSF)	14-21 days
Osteomyelitis	≥3 weeks