Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Diagnosis

Investigations

Blood for Complete Picture

  • Leucopenia (20-25%)

  • Thrombocytopenia by week 2 (in 10-15%)

Blood culture (1st week) - Gold standard

Stool culture (3rd week)

Positive in 30% of cases

Serological tests (Antibody Detection)

Widal test

Can be negative in ≤30% of cases

Typhidot test (Enzyme Immunoassay)

Modified Typhidot M

Serological tests (Antigen Detection)

Enzyme immune-assay, counterimmune electrophoresis and coagglutination tests

To detect somatic/flagella/Vi antigens of Salmonella Typhi

Molecular diagnostics

PCR - Similar sensitivity to blood cultures and lower specificity