Modified Duke: Major Criteria

Microbiologic Criteria: Select Any That Apply

Blood cultures positive for typical organism consistent with infective endocarditis.

Typical organisms

Staphylococcus aureus
Viridans group streptococci
Enterococcus spp.
Streptococcus bovis/gallolyticus
HACEK group: Haemophilus spp., Aggregatibacter spp., Cardiobacterium hominis, Eikenella corrodens, Kingella spp.

Persistently positive blood cultures for a typical organism from 2 positive blood cultures drawn >12hr apart, or the majority of ≥4 blood cultures are positive with first and last samples drawn at least one hour apart.

Single positive blood culture for Coxiella burnetii or anti-phase IgG antibody titer ≥1:800

Blood Cultures Pending

If blood culture data is pending, the Modified Duke Criteria cannot be accurately applied.