MRSA | Spectrum

Initial Empiric Treatment

Vancomycin 25 mg/kg loading dose followed by 15-20 mg/kg IV, target trough of 15-20 mg/L.

Frequency depends on renal function

Duration of Therapy

Short duration of therapy of two weeks (from the first negative blood culture) should only be provided to patients meeting all of the following criteria for uncomplicated Staphylococcus aureus bacteremia.

Infective endocarditis has been excluded
No implanted prostheses are present
Follow up blood cultures drawn 2-4 days after the initial set are sterile
The patient defervesces within 72 hours of initiation of effective antibiotic therapy
No evidence of metastatic infection is present on examination

Longer treatment duration is needed for patients who have complicated Staphylococcus aureus bacteremia. Strongly consider consultation with Infectious Diseases.