Spectrum: Local Antimicrobial Stewardship, for CHEO-OCTC

Guidelines/Allergies and Amoxicillin Challenge

Drug Reactions and Allergies

General Information

Non-IgE Mediated Reactions

IgE Mediated Reactions

Other Serious Reactions to Identify

The Consequences of "Labelling"

Is There A True Allergy?

Antibiotic options for true penicillin allergy OR while awaiting oral challenge

Amoxcillin Challenge

Amoxicillin Challenge Criteria

Amoxicillin Challenge Protocol

Implications of a Negative Oral Challenge Test

Additional Information

References
  1. Lagacé-Wiens P, Rubinstein E. Adverse reactions to β-lactam antimicrobials. Expert Opin Drug Saf 2012;11:381–99.
  2. Tucker MH, Lomas CM, Ramchandar N, Waldram JD. Amoxicillin challenge without penicillin skin testing in evaluation of penicillin allergy in a cohort of Marine recruits. J Allergy Clin Immunol Pract 2017;5:813–5.
  3. Kuruvilla M, Thomas J. Direct oral amoxicillin challenge without antecedent penicillin skin testing in low-risk patients. Ann Allergy, Asthma Immunol 2018 Nov;121(5):627-628.
  4. Mill C, Primeau M-N, Medoff E, Lejtenyi C, O’Keefe A, Netchiporouk E, et al. Assessing the Diagnostic Properties of a Graded Oral Provocation Challenge for the Diagnosis of Immediate and Nonimmediate Reactions to Amoxicillin in Children. JAMA Pediatr 2016;170:e160033.
  5. ShenoyES, Macy E, Rowe T, Blumenthal KG. Evaluation and management of penicillin allergy: A Review. JAMA 2019, January 15;321(2):188-199.