Cholecystitis - Uncomplicated

Note

For mild cases without features of infection (fever, increased WBC), antimicrobials generally not necessary

Discontinue therapy within 24h after source control (e.g. cholecystectomy - unless intra-operative evidence of infection beyond the gallbladder wall)

Cefazolin 1-2 gm IV q8h

OR

Cefuroxime 1.5 gm IV q8h

OR

Ceftriaxone 1-2 gm IV q24h

ALSO CONSIDER

Anaerobic coverage not necessary unless patient has biliary-enteric anastamosis (in which case add metronidazole 500mg IV q12h)

Levofloxacin 750mg IV q24h

OR

Ciprofloxacin 400mg IV q12h

AND

If concern for biliary-enteric anastamosis add metronidazole 500mg IV q12h