Spectrum: Local Antimicrobial Stewardship, for AHS Calgary Zone

Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

IV-15$/d PO-4$/d

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

750-1500mg IV q8h

500mg po q12h

Renal

General Information

Common Usage

Common Usage

Community Acquired Pneumonia with a macrolide; intraabdominal infection, epiglottitis

Adverse Effects

Adverse Effects

Allergy (immediate & delayed), positive Coombs, cytopenias, GI upset, diarrhea, abnormal liver enzymes

Major Interactions

Major Interactions

None significant

Pharmacology

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic