Spectrum: Local Antimicrobial Stewardship, for AHS Calgary Zone

Pancreatitis Empiric Rx

Note

Patients with severe infection are at risk of abdominal compartment syndrome - monitor intrabdominal pressures if possible

Abdominal Compartment Syndrome

Abdominal compartment syndrome (ACS) is defined as intra-abdominal pressure >20mmHg and new organ failure (renal, pulmonary or hemodynamic)

If ACS is suspected there are many treatment options available although a surgical consult should be sought to guide supportive measures and to assess for the possibility of a laparotomy

Empiric Antimicrobial Regimen

Duration of therapy depends on clinical course

In patients who fail to improve, surgical debridement of necrosis may be required and consultation with surgical team recommended

Meropenem 1g IV q8h

If patient not responding to antibiotics and has Candida risk factors consider empiric micafungin 100mg IV q24h

Candida risk factors

  • Colonization of multiple body sites

  • Immunocompromise

  • Broad-spectrum antibiotic use

  • Abdominal surgery

  • Central venous catheters

  • TPN

Reassess Therapy on Day 3

Day 3 Bundle