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Antimicrobials
Surgical opinion required for definitive management (i.e. cholecystectomy, cholecystostomy)
Bile for anaerobic C&S should be obtained unless mild uncomplicated acute cholecystitis
Uncomplicated community-acquired acute cholecystitis
Community-acquired acute cholecystitis with severe sepsis, or immunocompromised
Severe Sepsis
All of the following:
SIRS criteria (Two of HR>90, tachypnea, Temp >38 or <36, WBC >12 or <4),
Suspected/confirmed infection,
At least one new organ dysfunction (hypotension, elevated lactate, AKI, acute lung injury, DIC, neurologic or hepatic)
Health care-associated acute cholecystitis
Health care associated
A non pre-existent infection occurring ≥ 48 hours after hospital admission and/or within 90 days of discharge from a health care facility or regular outpatient visits (eg. dialysis or chemotherapy).