Spectrum: Local Antimicrobial Stewardship, for AHS Calgary Zone

Fosfomycin

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

$25/3g

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Female, Uncomplicated UTI: 3g PO once

Complicated or male UTI: 3g PO q2-3days x 3 doses

Renal

Dose post-hemodialysis

General Information

Common Usage

Common Usage

Urinary Tract Infection, especially involving ESBL producing organisms

Offlabel - prostatitis

Adverse Effects

Adverse Effects

GI upset, esp. diarrhea
Headache
Eosinophilia, neutropenia
Hypokalemia

Major Interactions

Major Interactions

No significant

Additional Information

Additional Information

IV formulation not available

Pharmacology

Pharmacology

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6.0

Urine penetration: Therapeutic