Spectrum: Local Antimicrobial Stewardship, for AHS Calgary Zone

Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$1/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Cystitis: Macrobid 100mg PO BID

Renal

General Information

Common Usage

Common Usage

Uncomplicated cystitis in females with normal renal function

Adverse Effects

Adverse Effects

Interstitial pneumonitis and fibrosis esp. with prolonged use

Peripheral neuropathy

Major Interactions

Major Interactions

Antacids decrease absorption

Additional Information

Additional Information

Think of this drug as a urinary antiseptic.

Not recommended in males due to inadequate tissue penetration, esp. with possible occult prostatitis

Pharmacology

Pharmacology

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic