Spectrum: Local Antimicrobial Stewardship, for AHS Calgary Zone

Norfloxacin

C. diff Risk

High

Oral Bioavailability

Moderate

Approximate Cost

$2/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

400mg PO BID

Renal

General Information

Common Usage

Common Usage

Prophylaxis of spontaneous bacterial peritonitis

Uncomplicated UTI

Drug Monitoring

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • CNS toxicity including confusion, psychosis

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • Rash

Major Interactions

Major Interactions

Other QTc prolonging agents

Divalent cations - decreased absoprtion

Methadone - increased seizures

Thyroid replacement - decreases T

Warfarin - increased INR

Pharmacology

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Urine penetration: Therapeutic