Low
Excellent
IV$100/d PO$1/d
Urinary tract infections, susceptible MRSA infections, Stenotrophomonas infections, Pneumocystis jirovecii pneumonia (treatment or prophylaxis)
Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia
Stevens Johnson syndrome/toxic epidermal necrolysis, other rashes, gastrointestinal upset common, bone marrow suppression, hyperkalemia, renal failure, hepatitis, aseptic meningitis
ACEi - increased serum potassium level
Increases amantadine levels
Decreases cyclosporine
Methotrexate- marrow suppression
Increases phenytoin
Increases rifampin
Increases INR with warfarin
Antimicrobial class: Sulfonamide - Antifolate
Pregnancy category: C
Average serum half life: 10.0
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
