Spectrum: Local Antimicrobial Stewardship, for AHS Calgary Zone

Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$35/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

Renal

General Information

Common Usage

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections esp enterococcus and listeria

Adverse Effects

Adverse Effects

Allergy and rash as for all beta-lactams

EBV related rash (not allergy)

Rare: cytopenias, +ve Coombs

Major Interactions

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Pharmacology

Antimicrobial class: aminopenicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic