High
NA
$30/day
Empiric therapy for bacterial meningitis, pneumonia (in combination with a macrolide), intra-abdominal infection including SBP, musculoskeletal i.e. septic arthritis, and urinary tract infection.
Rash, localized phlebitis at injection site, allergy.
Positive Coombs test, neutropenia, abnormalities in liver enzymes.
Diarrhea and CDI.
Prefer ceftriaxone for CNS infection in renal failure.
Cefotaxime may be automatically substituted by AHS pharmacy to ceftriaxone due to cost and ease of dosing.
If you order it specifically, specify no substitution otherwise preference is for ceftriaxone
Antimicrobial class: 3rd Generation Cephalosporin
Pregnancy category: B
Average serum half life: 1.5
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
