Penicillin VK

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

$0.50/day

Dosing

250-500mg PO q6-8h

General Information

Common Usage

Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract)

Prophylaxis after rheumatic fever

Drug Monitoring

Monitor for allergy. Periodic CBC, SCr

Adverse Effects

Allergy (anaphylaxis) and other rash

Cytopenias, Positive Coombs, Eosinophilia

Serum sickness

AIN

Major Interactions

No significant

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1.0

Lung penetration: Therapeutic

Urine penetration: Therapeutic