Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

CDI Ileus

Empiric Therapy

Vancomycin intracolonic Q6H via retention enema

PLUS

Metronidazole 10 mg/kg IV Q8H
(Max Dose: 500 mg)

Intracolonic Vancomycin Pediatric Dosing

  • 250mg in 50mL for 1-3 years of age
  • 375mg in 75mL for 3-9 years of age
  • 500mg in 100mL for 10 years of age and older

Do not use in neutropenic patients

Additional Recommendations

Discontinuing Other Medications