Generally susceptible to Penicillins and Cephalosporins

Always susceptible to Vancomycin, Levofloxacin, and Linezolid

Variably susceptible to TMP-SMX, Macrolides, and Clindamycin

Resistance to Penicillin and Cephalosporins exists which is why Vancomycin is part of empiric therapy for meningitis

For invasive infections, susceptibility profiles with MIC data should be obtained