Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing

General Information

Common Usage

Common Usage

Pathogen directed therapy for CNS, intravascular, intra-abdominal, urinary and other infections esp enterococcus and listeria

As part of empiric therapy for early onset sepsis in neonates

Drug Monitoring

Drug Monitoring

Renal & liver function

CBC with differential

Adverse Effects

Adverse Effects

  • Allergy and rash

  • EBV related rash (not allergy)

  • Rare: cytopenias, +ve Coombs

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin

Average serum half life:

  • Neonates
    PNA 2-7days: 4 hours
    PNA 8-14 days: 2.8 hours
    PNA 15-30 days: 1.7 hour

  • Pediatrics: 1-1.8 hours

  • Anuric patients: 8-20 hours

Biliary Penetration: Detectable levels but lower than serum

Route of Elimination:

  • 90% excreted unchanged in urine within 24 hours