Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Azithromycin

C. diff Risk

Medium

Oral Bioavailability

Low (20 to 40%)

Approximate Cost

IV$ PO$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

Neonatal

20 mg/kg, PO, daily

20 mg/kg, IV, q24hr. Infuse over 60 minutes

Renal

Dose adjustment not necessary.
Use with caution if CrCl <10mL/minute.

Hepatic

Use with caution in hepatic impairment.

General Information

Common Usage

Common Usage

  • Community acquired pneumonia

  • Pertussis

  • Upper respiratory tract infections

  • Chlamidial infections

  • Mycobacterial infections

  • Mycobacterium avium complex (MAC) prophylaxis in HIV patients

Drug Monitoring

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

Adverse Effects

Prolongation of QTc interval

Major Interactions

Major Interactions

While less risk of interaction compared to other macrolides, several potential CYP450 interactions may occur; consult a pharmacist for for more details

Avoid concurrent use with other drugs that prolong QTc

Pharmacology

Pharmacology

Antimicrobial class: Macrolide

Average serum half life: Pediatrics: 54.5 hours

Route of Elimination: 50% excreted unchanged in bile

6-14% excreted unchanged in urine