Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Aztreonam

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$$$$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing

General Information

Common Usage

Common Usage

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent

Nebulized form used in cystic fibrosis patients

Drug Monitoring

Drug Monitoring

Renal and liver function

CBC

Adverse Effects

Adverse Effects

  • Elevated liver enzymes

  • Cytopenias

  • Eosinophilia

  • Phlebitis at injection site

  • Rash/allergy

  • CNS toxicity

  • Hypotension

  • Seizures

  • Increased SCr

Additional Information

Additional Information

Use with caution in patients with congenital or acquired arginase deficiency or other conditions where tolerance to L-Arginine may be limited

Pharmacology

Pharmacology

Antimicrobial class: Monobactam

Average serum half life: Neonates:

  • <7 days, ≤2.5 kg: 5.5 to 9.9 hours

  • <7 days, >2.5 kg: 2.6 hours

  • 1 week to 1 month: 2.4 hours

  • Children 2 months to 12 years: 1.7 hours

  • Children with cystic fibrosis: 1.3 hours

Route of Elimination: 60% to 70% excreted unchanged in the urine by active tubular secretion and glomerular filtration; 12% excreted in feces