Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing

General Information

Common Usage

Common Usage

Skin and soft tissue infection (i.e. cellulitis)

Surgical prophylaxis

Susceptible Staphylococcal, Streptococcal, and Gram negative infections

Adverse Effects

Adverse Effects

Allergy (immediate or delayed)

Can cause positive Coombs, cytopenias

Major Interactions

Major Interactions

Probenecid - prolonged half-life

Drug interaction has been used therapeutically to give once daily cefazolin

Pharmacology

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Average serum half life: Neonates: 3-5 hours
Adults: 1.8 hours

Route of Elimination: Excreted unchanged in urine