Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Daptomycin

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$$$$$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Pediatric

10 mg/kg, IV, q24hr, Infuse over 30 minutes

Neonatal

6 mg/kg, IV, q12hr(s), Infuse over 60 minutes

General Information

Common Usage

Common Usage

Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC>=2) and VRE including endovascular infection

Drug Monitoring

Drug Monitoring

Creatine kinase weekly, renal function

Adverse Effects

Adverse Effects

  • Myopathy including rhabdomyolysis

  • GI side effects common

  • Rash

  • Phlebitis

  • Increased INR

Major Interactions

Major Interactions

Statins and fibrates: monitor creatine kinase or hold while on daptomycin therapy (increased myopathy)

Additional Information

Additional Information

Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection

Pharmacology

Pharmacology

Antimicrobial class: Cyclic lipopeptide, depolarizes bacterial cell membrane

Average serum half life: Neonates and Infants <3 months: 6.2 hours
Children: 5 to 7 hours

Route of Elimination: 78% of the dose excreted in urine as unchanged drug; feces (6%)