Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Doxycycline

C. diff Risk

Low

Oral Bioavailability

Excellent (90 to 100%)

Approximate Cost

IV$$$ PO$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

Other

Doxycycline can be safely administered for short durations (< 21 days) regardless of age (AAP Red Book 2018, Sec. 4)

General Information

Acceptable Uses

Acceptable Uses

  • Skin and soft tissue infection

  • Methicillin resistant staphylococcus aureus infections

  • Community acquired pneumonia

  • Malaria prophylaxis

  • Zoonoses

First Line Indications

First Line Indications

  • Skin and soft tissue infections

  • Rickettsia and other tick-borne diseases

  • Chlamydia

  • Mycoplasma

Adverse Effects

Adverse Effects

  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining (less than tetracycline)

Major Interactions

Major Interactions

Antacids, bismuth, multivitamin and mineral supplements - decreased absorption
Barbiturates
Carbamazepine
Fosphenytoin/phenytoin
Penicillins

Oral Liquids

Oral Liquids

25mg/5ml suspension

Tablet/Capsule Strengths

Tablet/Capsule Strengths

100mg capsule

Additional Information

Additional Information

  • Avoid iron, magnesium, calcium, and dairy products for at least one hour before or two hours after doxycycline administration

  • Take with food to lessen nausea

  • Take with lots of water and not before bed to decrease occurence of esophagitis

Pharmacology

Pharmacology

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Biliary penetration: Good

CSF penetration: Poor

Lung penetration: Good

Urine penetration: Good

Route of Elimination: In the urine (40%) and feces (30%)

Metabolism: Partially inactivated in GI tract by chelate formation