Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Penicillin G (Parenteral)

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Pediatric

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing

General Information

Common Usage

Common Usage

Therapy of Streptococcal and other documented susceptible infections

Syphilis

Drug Monitoring

Drug Monitoring

  • Renal and hepatic function

  • CBC with differential

  • Hypersensitivity reactions

  • IV site for phlebitis

Adverse Effects

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

Pharmacology

Pharmacology

Antimicrobial class: penicillin

Average serum half life: Neonates: <6 days: 3.2 to 3.4 hours. 7 to 13 days: 1.2 to 2.2 hours. >14 days: 0.9 to 1.9 hours.
Pediatrics: 0.5-1.2 hours.
Adults normal renal function: 30- 50 mintes

Biliary Penetration: Detectable but lower than serum

Route of Elimination: Renal (58% to 85% unchanged drug)