Vancomycin (Enteral)

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

Poor (Less than 20%)

Approximate Cost

$

Spectrum Of Activity

Dosing

10 mg/kg, PO, 4xdaily. Max dose=125mg

There are no dosage adjustments provided in manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption

There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption

General Information

Common Usage

Only indication is in the therapy of C. difficile infection

Drug Monitoring

Possibility of accumulation in severe renal dysfunction; consider checking a vancomycin level in dialysis patients

Adverse Effects

Nausea, vomiting, diarrhea

Major Interactions

Avoid concurrent administration of oral vancomycin and bile acid sequestrants (may diminish therapeutic effect of vancomycin)

Additional Information

  • No oral absorption

  • May increase vancomycin resistant enterococci colonization in the gut

  • Cost listed above reflects oral liquid

  • Capsules are almost 10x more costly

Pharmacology

Antimicrobial class: Glycopeptide

Average serum half life: Serum half life not available due to low systemic absorption

Route of Elimination: Primarily feces as limited absorption