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Pathogens
Antimicrobials
Low
Poor (Less than 20%)
$
10 mg/kg, PO, 4xdaily. Max dose=125mg
There are no dosage adjustments provided in manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption
Only indication is in the therapy of C. difficile infection
Possibility of accumulation in severe renal dysfunction; consider checking a vancomycin level in dialysis patients
Nausea, vomiting, diarrhea
Avoid concurrent administration of oral vancomycin and bile acid sequestrants (may diminish therapeutic effect of vancomycin)
No oral absorption
May increase vancomycin resistant enterococci colonization in the gut
Cost listed above reflects oral liquid
Capsules are almost 10x more costly
Antimicrobial class: Glycopeptide
Average serum half life: Serum half life not available due to low systemic absorption
Route of Elimination: Primarily feces as limited absorption