Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

IV$$$ PO$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Pediatric

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing

General Information

Common Usage

Common Usage

Community acquired pneumonia

Adverse Effects

Adverse Effects

  • Allergy (immediate & delayed)

  • positive Coombs

  • Cytopenias

  • GI upset

  • Diarrhea

  • Abnormal liver enzymes

Pharmacology

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Average serum half life: Neonates: PNA≤3 days median 5.8 hours.<br> PNA ≥8 median 1.6-3.8 hours.<br> Pediatrics: 1.4-1.9 hours

Route of Elimination: 66-100% as unchanged drug in urine by both glomerular filtration and tubular secretion