High
Good (70 to 90%)
IV/PO $
Treatment
Pyelonephritis
Lower respiratory tract infections
Skin and soft tissue infections
Bone and joint infections
Complicated intra-abdominal infections
Salmonellosis
Infectious diarrhea
Febrile neutropenia
Endocarditis
Prophylaxis
Postexposure prophylaxis of anthrax
Surgical site infection
Invasive meningococcal disease
Dizziness
Insomnia
Rash
N/V
Abdominal pain
Tendinopathy and rupture
Retinal detachment
Peripheral neuropathy
QTc prolongation
Strong CYP1A2 inhibitor and weak CYP3A4 inhibitor - Multiple interactions possible
QTc prolongation - Increased risk with other agents that prolong QTc
AVOID concomitant administration with antacids, multivitamin & mineral supplements - Space doses by 2 hours
Do not administer supsension through feeding tubes. Crush and mix tablet instead
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: Pediatrics: 4-5 hours
Biliary penetration: Good
CSF penetration: 26%
Lung penetration: Excellent
Urine penetration: Excellent kidney penetration
Route of Elimination: 30% to 70% excreted as unchanged drug in urine via glomerular filtration and active tubular secretion; 20% excreted in feces primarily from biliary excretion; <1% excreted in bile as unchanged drug
Metabolism: Partially hepatic
