Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Piperacillin-Tazobactam

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing

General Information

Common Usage

Common Usage

Broad spectrum agent with anti-pseudomonal activity used for severe infections including:

  • Pneumonia

  • Intra-abdominal/hepatobiliary

  • UTI

  • Polymicrobial skin and soft tissue infection

  • Febrile neutropenia

Drug Monitoring

Drug Monitoring

  • Renal and hepatic function

  • CBC with differential

  • C. difficile-associated diarrhea

  • Hypersensitivity reactions

  • IV site for phlebitis

Adverse Effects

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias (esp. thrombocytopenia)

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Pharmacology

Pharmacology

Biliary Penetration: Good (20% biliary excretion)