Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Vancomycin IV

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing

General Information

Common Usage

Common Usage

Suspected or proven MRSA

Coagulase-negative Staphylococcal infections

Enterococcal infections

Drug Monitoring

Drug Monitoring

Target serum levels: 10 to 20 mg/L

Monitor serum creatinine and urine output throughout therapy

Adverse Effects

Adverse Effects

  • Red man syndrome (histamine release - slow down infusion)

  • Nephrotoxicity

  • Cytopenias

Major Interactions

Major Interactions

Aminoglycosides may potentiate nephrotoxicity

Use caution and increase monitoring of renal function when used with concomitant nephrotoxins

Pharmacology

Pharmacology

Antimicrobial class: glycopeptide

Average serum half life: Newborns: 6 to 10 hours.
Infants and Children 3 months to 4 years: 4 hours.
Children and Adolescents >3 years: 2.2 to 3 hours

Biliary Penetration: Low (5% biliary excretion)

Route of Elimination: Primarily via glomerular filtration; excreted as unchanged drug in the urine (80% to 90%)