Spectrum: Local Antimicrobial Stewardship, for Fraser Health

Non-Pregnant Females & Males (Acute cystitis)

Duration of therapy

Females: 3-5 days (see specific dosing below)

Males: 7 days

First Line

Nitrofurantoin (MacroBID) 100 mg PO BID x 5 days (CrCl>30 only)

Second Line

TMP/SMX 1 DS tab PO BID x 3 days

OR

Amoxicillin-clavulanate 875-125 mg one tab PO BID x 5 days

Third Line

Cefixime 400 mg PO daily x 5 days

OR

Ciprofloxacin 500 mg PO BID x 3 days

OR

Fosfomycin 3 g PO once
(Males: 3 g PO every 3 days x 3 doses)

Note

Oral regimen preferred from outset in most patients. If started on parenteral agent, switch to oral agent as soon as feasible