Humans are the reservoir - fecal-oral transmission.
Increased prevalence in developing countries.
Highest prevalence South Asia
Fever in Returning Traveler, enteric fever, FUO, bacteremia, intra-abdominal abscess, meningitis, endovascular infection (endocarditis, infected aneurysm)
High rates of cipro resistance in Indian Subcontinent.
Vaccination only 50% efficacy.
Chronic carriage associated with gallbladder disease - think "Typhoid Mary"
