Anti-pseudomonal drugs: pip-tazo, ceftazidime, cefepime, meropenem, imipenem, aztreonam, ciprofloxacin, levofloxacin, aminoglycosides, colistin

Resistance is variable to all of these agents through various mechanisms. Refer to local antibiogram.

Empiric double coverage often used for critically ill patients:

anti-pseudomonal beta-lactam (pip-tazo or meropenem)
+
cipro or aminoglycoside (gentamicin or tobramycin)