Generally susceptible: penicillin, amoxicillin, ceftriaxone, vancomycin, moxifloxacin.

Variably susceptible to TMP-SMX, macrolides, and clindamycin

Rare resistance to ceftriaxone is why vancomycin is part of empiric therapy for meningitis

For invasive infections, susceptibility profiles with MIC data should be obtained