Vancomycin 125 mg PO QID
Risk factors for recurrent disease
Fidaxomicin 200 mg PO BID
Severe disease (toxic megacolon in ICU)
Vancomycin 500 mg PO q6h
PLUS
Metronidazole 500 mg IV q8h
Nosocomial more common than community onset diarrhea usually after taking antibiotics.
Can occur in outbreaks.
Recurrence is very common therefore previous history of C. difficile is a risk factor.
Antacids, especially proton-pump inhibitors, and chemotherapy also increase risk.
Wide range of symptoms possible.
Profuse, watery diarrhea
Pseudomembranous colitis or toxic megacolon.
General treatment duration 10 days. May be longer in poor responders or patients on concomitant antibiotics.
Cholestyramine may bind other oral medication (ie PO vanco). Not recommended.
Metronidazole no longer recommended first line by IDSA guidelines.
In refractory cases, stool transplants have been effective (refer to St. V GI).
