• Ciprofloxacin/levofloxacin

• Cefepime

• Piperacillin-tazobactam

• Carbapenem

These organisms have the ability produce inducible beta-lactamase which cause failure of 3rd generation beta-lactam therapy, despite in vitro susceptibility - ie do not use ceftriaxone for serious infections such as bacteremia or osteomyelitis