Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Peramivir

Restricted
Restricted

C. diff Risk

None

Oral Bioavailability

NA

Approximate Cost

See below

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

CrCl 30-50 mL/min200 mg q24h

CrCl < 30 mL/min100 mg q24h

Hemodialysis100 mg x 1 then 100 mg 2 hours after each HD session

Adult

ONLY for NPO patient600 mg IV q24h

General Information

Cost Dollar

Cost

Very very expensive. Requires ID provider approval.

Adverse Effects

Adverse Effects

  •  Diarrhea

  •  Vomiting

  •  Constipation

  •  Insomnia

  •  Hypertension

  •  AST/ALT increase

Additional Information

Additional Information

  •  Alternative option: oseltamivir via ng or PO

  •  Requires Infectious Diseases approval for use

Pharmacology

Pharmacology

Antimicrobial class: Antiviral Agent; Neuraminidase Inhibitor

Pregnancy category: Extremely limited data

Average serum half life: 20 hours