Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Cefoxitin

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$22-33/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

CrCl 30-502 g IV q8-12 hours

CrCl 10-292 g IV q12-24h

CrCl < 10 or hemodialysis1 g q24h (supplement additional 1-2 g post-HD)

Adult

2 g IV q4-6 hours

General Information

Common Usage

Common Usage

  •  Lower respiratory tract abscesses

  •  Gynecologic infections (PID, entdometritis)

  •  Surgical prophylaxis

Additional Information

Additional Information

Alternative option instead of cefoxitin for pelvic inflammatory disease is Ceftriaxone + Metronidazole

Pharmacology

Pharmacology

Antimicrobial class: Intravenous Cephamycin (placed in 2nd generation Cephalosporin)

Pregnancy category: B

Average serum half life: <1 hour

CSF penetration: poor

Route of Elimination: mostly renal